And thy issue, which thou begettest after them, shall be thine,.... The children of Joseph, that either were, or would be begotten after Ephraim and Manasseh; though whether ever any were is not certain; and this is only mentioned by way of supposition, as Jarchi interprets it, "if thou shouldest beget", &c. these should be reckoned his own, and not as Jacob's sons, but be considered as other grandchildren of Jacob's were, and not as Ephraim and Manasseh:

and shall be called after the name of their brethren in their inheritance; they should not have distinct names, or make distinct tribes, or have a distinct inheritance; but should be called either the children of Ephraim, or the children of Manasseh, and should be reckoned as belonging either to the one tribe, or the other, and have their inheritance in them, and with them, and not separate.

And thy issue, which thou begettest after them, shall be thine, and shall be called after the name of their brethren in their inheritance.

48:1-7 The death-beds of believers, with the prayers and counsels of dying persons, are suited to make serious impressions upon the young, the gay, and the prosperous: we shall do well to take children on such occasions, when it can be done properly. If the Lord please, it is very desirable to bear our dying testimony to his truth, to his faithfulness, and the pleasantness of his ways. And one would wish so to live, as to give energy and weight to our dying exhortations. All true believers are blessed at their death, but all do not depart equally full of spiritual consolations. Jacob adopted Joseph's two sons. Let them not succeed their father, in his power and grandeur in Egypt; but let them succeed in the inheritance of the promise made to Abraham. Thus the aged dying patriarch teaches these young persons to take their lot with the people of God. He appoints each of them to be the head of a tribe. Those are worthy of double honour, who, through God's grace, break through the temptations of worldly wealth and preferment, to embrace religion in disgrace and poverty. Jacob will have Ephraim and Manasseh to know, that it is better to be low, and in the church, than high, and out of it.