And he said unto me, Depart - Because the Christians at Jerusalem would not receive him.

Far hence - Paul traveled far in the pagan nations. A large part of his ministry was spent in remote countries, and in the most distant regions then known. See Romans 15:19.

I will send thee far hence unto the Gentiles - This was the particular appointment of St. Paul: he was the apostle of the Gentiles; for, though he preached frequently to the Jews, yet to preach the Gospel to the Gentiles, and to write for the conversion and establishment of the Gentile world, were his peculiar destination. Hence we find him and his companions travelling every where; through Judea, Phoenicia, Arabia, Syria, Cilicia, Pisidia, Lycaonia, Pamphylia, Galatia, Phrygia, Macedonia, Greece, Asia, the Isles of the Mediterranean Sea, the Isles of the Aegean Sea, Italy, and some add Spain and even Britain. This was the diocess of this primitive bishop: none of the apostles traveled, none preached, none labored as this man; and, we may add, none was so greatly owned of God. The epistles of Peter, John, James, and Jude, are great and excellent; but, when compared with those of Paul, however glorious they may be, they have no glory comparatively, by reason of that glory which excelleth. Next to Jesus Christ, St. Paul is the glory of the Christian Church. Jesus is the foundation; Paul, the master-builder.

And he said unto me, depart,.... At once from Jerusalem, and out of the land of Judea:

for I will send thee far hence unto the Gentiles; to the nations afar off, even as far as Illyricum, Pannonia, or Hungary, where the apostle went and preached, Romans 15:19 and so by a divine mission and commission he became the apostle of the Gentiles, and preached the Gospel among them with great success, to the conversion of many thousands of them, and to the planting of many churches in the midst of them.

Gentiles

"The fatal word, which hitherto he had carefully avoided, but which it was impossible for him to avoid any longer, was enough....The word 'Gentiles,' confirming all their worst suspicions, fell like a spark on the inflammable mass of their fanaticism" (Farrar, "Life and Work of Paul").

And he said unto me, Depart: for I will send thee far hence unto the Gentiles.

22:21 Depart: for I will send thee far hence unto the Gentiles. Thus by the command of his Lord his life-work was placed beyond the pale of Israel.

21. depart for I will send thee far hence unto the Gentiles-that is, "Enough; thy testimony is not to be thrown away upon Jerusalem; the Gentiles, afar off, are thy peculiar sphere."

22:12-21 The apostle goes on to relate how he was confirmed in the change he had made. The Lord having chosen the sinner, that he should know his will, he is humbled, enlightened, and brought to the knowledge of Christ and his blessed gospel. Christ is here called that Just One; for he is Jesus Christ the righteous. Those whom God has chosen to know his will, must look to Jesus, for by him God has made known his good-will to us. The great gospel privilege, sealed to us by baptism, is the pardon of sins. Be baptized, and wash away thy sins; that is, receive the comfort of the pardon of thy sins in and through Jesus Christ, and lay hold on his righteousness for that purpose; and receive power against sin, for the mortifying of thy corruptions. Be baptized, and rest not in the sign, but make sure of the thing signified, the putting away of the filth of sin. The great gospel duty, to which by our baptism we are bound, is, to seek for the pardon of our sins in Christ's name, and in dependence on him and his righteousness. God appoints his labourers their day and their place, and it is fit they should follow his appointment, though it may cross their own will. Providence contrives better for us than we do for ourselves; we must refer ourselves to God's guidance. If Christ send any one, his Spirit shall go along with him, and give him to see the fruit of his labours. But nothing can reconcile man's heart to the gospel, except the special grace of God.