Last of all ... - Mark adds that this was an only son, greatly beloved.

This beautifully and most tenderly exhibits the love of God in sending his only Son, Jesus Christ, into the world to die for people. Long had he sent the prophets, and they had been persecuted and slain. There was no use in sending any more prophets to the people. They had done all that they could do. God had one only-begotten and well-beloved Son, whom he might send, and whom the world "ought" to reverence even as they should the Father, John 5:23. God is often represented in the Bible as giving his Son, his only-begotten and wellbeloved Son, for a lost world, John 3:16-17; 1 John 4:9, 1 John 4:14; Romans 8:3, Romans 8:32; Galatians 4:4.

Saying, They will reverence my son - To "reverence" means to honor, to esteem, to show deference to. It is that feeling which we have in the presence of one who is greatly our superior. It means to give to such a person, in our feelings and our deportment, the honor which is due to his rank and character.

Last of all he sent - his son - This requires no comment. Our Lord plainly means himself.

They will reverence - Εντραπησονται, they will reflect upon their conduct and blush for shame because of it, when they see my son. So the Syric and Persic.

But last of all,.... In the last times, in the last days, in the end of the world, the Jewish world, at the close of their ecclesiastic and civil state; after all the prophets had been sent, and finished their course, came the greatest prophet of all, to seal up the vision and prophecy:

he sent unto them son; not a servant as before, but a son; his own son, his only begotten son, the son of his love, his dearly beloved one; him he sent to these husbandmen the Jews. The Son of God, the Lord Jesus Christ, was sent only to the house of Israel: he was the minister of the circumcision; he was the great prophet raised up among them, and was sent to bless them, by turning them from their iniquities; he came to them, to his own, to them of his own nation, but they received him not:

saying, they will reverence my son. The Son of God is to be reverenced equally as his Father, since he is in nature and glory equal to him; and it is the will of his Father he should be so reverenced, as he is by the angels in heaven, and by the saints, both in heaven and in earth; but did these husbandmen reverence him? no; they despised and rejected him; they reproached and traduced him, as the vilest of men, and used him in the most cruel and barbarous manner. And did not his Father know this? yes; this is certain from his omniscience, which reaches to all future events, the most minute and contingent; and from the predictions of the usage of these persons of him, delivered long before it came to pass. Luke says, "it may be they will reverence him": so that it was not a positive affirmation, that they would do it, and which also is to be understood after the manner of men: that humanly speaking, it might be expected that they would give him reverence, in consideration of the dignity of his person, his character, and relation to God, which was his due and their duty; but he had a very different treatment from them.

They will reverence (ἐνταραπήσονται)

The verb literally means to turn toward; hence to give heed to, pay respect to.

But last of all he sent unto them his son, saying, They will reverence my son.

21:37 Last of all he sent unto them his son. This was the last and crowning effort of divine mercy; after which, on the one side, all the resources, even of heavenly love, are exhausted; on the other, the measure of sins is perfectly filled up.

37. But last of all he sent unto them his son, saying, They will reverence my son-In Mark (Mr 12:6) this is most touchingly expressed: "Having yet therefore one son, His well-beloved, He sent Him also last unto them, saying, They will reverence My Son." Luke's version of it too (Lu 20:13) is striking: "Then said the lord of the vineyard, What shall I do? I will send My beloved Son: it may be they will reverence Him when they see Him." Who does not see that our Lord here severs Himself, by the sharpest line of demarcation, from all merely human messengers, and claims for Himself Sonship in its loftiest sense? (Compare Heb 3:3-6). The expression, "It may be they will reverence My Son," is designed to teach the almost unimaginable guilt of not reverentially welcoming God's Son.

21:33-46 This parable plainly sets forth the sin and ruin of the Jewish nation; and what is spoken to convict them, is spoken to caution all that enjoy the privileges of the outward church. As men treat God's people, they would treat Christ himself, if he were with them. How can we, if faithful to his cause, expect a favourable reception from a wicked world, or from ungodly professors of Christianity! And let us ask ourselves, whether we who have the vineyard and all its advantages, render fruits in due season, as a people, as a family, or as separate persons. Our Saviour, in his question, declares that the Lord of the vineyard will come, and when he comes he will surely destroy the wicked. The chief priests and the elders were the builders, and they would not admit his doctrine or laws; they threw him aside as a despised stone. But he who was rejected by the Jews, was embraced by the Gentiles. Christ knows who will bring forth gospel fruits in the use of gospel means. The unbelief of sinners will be their ruin. But God has many ways of restraining the remainders of wrath, as he has of making that which breaks out redound to his praise. May Christ become more and more precious to our souls, as the firm Foundation and Cornerstone of his church. May we be willing to follow him, though despised and hated for his sake.