Compare Jeremiah 2:30; Hebrews 11:37; Isaiah 57:1-4. According to tradition, Isaiah was among the first to perish. More than a century afterward, the final judgment upon Jerusalem was felt to be in an special way the punishment of Manasseh's bloody persecution of God's people (marginal reference).

Shed innocent blood very much - Like the deities he worshipped, he was fierce and cruel; an unprincipled, merciless tyrant: he slew innocent people and God's prophets.

Moreover, Manasseh shed innocent blood very much,.... Putting to death the prophets that reproved him and his people for their idolatries, and such who would not comply therewith; and it is commonly said, both by Jewish and Christian writers, that Isaiah was slain, and even sawn asunder by him; see Gill on Hebrews 11:37,

till he had filled Jerusalem from one end to another; a metaphor taken from filling a vessel brimful:

beside his sin wherewith he made Judah to sin, in doing that which was evil in the sight of the Lord; the sin of idolatry he drew them into, and even obliged them to commit.

Manasseh also sinned grievously by shedding innocent blood till Jerusalem was quite filled with it. לפה פּה, from one edge to the other, see at 2 Kings 10:21. This statement has been paraphrased by Josephus thus (Ant. x. 3, 1): Manasseh slew πάντας ὁμῶς τοὺς δικαίους τοὺς ἐν τοῖς Ἑεβραίοις, and did not spare even the prophets, with the additional clause, which exaggerates the thing: καὶ τούτων δέ τινας καθ ̓ ἡμέραν ἀπέσφαξε, ὥστε αἵματι ῥεῖσθαι τὰ Ἱεροσόλυμα.

(Note: The widespread Jewish and Christian legend, that Manasseh put to death the prophet Isaiah, and indeed had him sawn in sunder, to which there is an allusion in Hebrews 11:37, also belongs here. (See Delitzsch, Comm. on Isaiah, p. 5.))

Moreover Manasseh shed {s} innocent blood very much, till he had filled Jerusalem from one end to another; beside his sin wherewith he made Judah to sin, in doing that which was evil in the sight of the LORD.

(s) The Hebrews write that he slew Isaiah the prophet, who was his father-in-law.

21:16 Blood - The blood of those prophets and righteous men who either reproved his sinful practices, or refused to comply with his wicked commands. His sin - His idolatry, which is called sin, by way of eminency. The tradition of the Jews is, that he caused Isaiah in particular to be sawn asunder.

from...: Heb. from mouth to mouth

16. Moreover Manasseh shed innocent blood-Not content with the patronage and the practice of idolatrous abomination, he was a cruel persecutor of all who did not conform. The land was deluged with the blood of good men; among whom it is traditionally said Isaiah suffered a horrid death, by being sawn asunder (see on [352]Heb 11:37).

21:10-18 Here is the doom of Judah and Jerusalem. The words used represent the city emptied and utterly desolate, yet not destroyed thereby, but cleansed, and to be kept for the future dwelling of the Jews: forsaken, yet not finally, and only as to outward privileges, for individual believers were preserved in that visitation. The Lord will cast off any professing people who dishonour him by their crimes, but never will desert his cause on earth. In the book of Chronicles we read of Manasseh's repentance, and acceptance with God; thus we may learn not to despair of the recovery of the greatest sinners. But let none dare to persist in sin, presuming that they may repent and reform when they please. There are a few instances of the conversion of notorious sinners, that none may despair; and but few, that none may presume.