I go my way - See the notes at John 7:33.

Ye shall die in your sins - That is, you will seek the Messiah; you will desire his coming, but the Messiah that you expect will not come; and, as you have rejected me, and there is no other Saviour, you must die in your sins. You will die unpardoned, and as you did not seek me where you might find me, you cannot come where I shall be. Observe:

1. All those who reject the Lord Jesus must die unforgiven. There is no way of pardon but by him. See the notes at Acts 4:12.

2. There will be a time when sinners will seek for a Saviour but will find none. Often this is done too late, in a dying moment, and in the future world they may seek a deliverer, but not be able to find one.

3. Those who reject the Lord Jesus must perish. Where he is they cannot come. Where he is is heaven. Where he is not, with his favor and mercy, there is hell; and the sinner that has no Savior must be wretched forever.

Then said Jesus again unto them - He had said the same things to them the day before. See John 7:34.

Ye shall seek me - When your calamities come upon you, ye shall in vain seek for the help of the Messiah, whom ye now reject, and whom ye shall shortly crucify.

Then said Jesus again unto them,.... It may be, immediately after he had said the above words; or rather some time after, it may be on the same day:

I go my way; meaning, the way of all flesh, or that he should die: the way of speaking shows, that his death was certain, a determined thing; which must be, and yet was voluntary: he was not driven, nor forced, but went freely; this being the path, the way, through which he must enter into his kingdom and glory:

and ye shall seek me; that is, shall seek the Messiah, as their deliverer and Saviour, when in distress; and whom he calls himself, because he was the true Messiah, and the only Saviour and Redeemer of his people, in a spiritual sense; otherwise they would not, nor did they seek Jesus of Nazareth:

and shall die in your sins; or "in your sin"; so it is in the Greek text, and in the Vulgate Latin, and Persic versions: meaning, in their sin of unbelief, and rejection of him the true Messiah: the sense is, that in the midst of their calamities, which should come upon them, for their sin against him, they should in vain seek for the Messiah, as a temporal deliverer of them; for their nation, city, and temple, and they therein should utterly perish, for their iniquity; and their ruin would not only be temporal, but eternal: since it follows,

whither I, go ye cannot come, signifying, that whereas he was going to his Father, to heaven and glory; to enjoy eternal happiness at his Father's right hand, in the human nature; they should never come there, but whilst many sat down in the kingdom of heaven, with their fathers Abraham, Isaac, and Jacob, who should come from afar, they would be shut out, and not suffered to enter in.

Then (οὖν)

Properly, therefore, connecting the fact of Jesus' continuing to speak with His freedom from arrest.

Said Jesus

Omit Jesus, and read, He said therefore.

Go away (ὑπάγω)

Withdraw myself from you; this sense being emphasized by the succeeding words, ye shall seek me. In expressing one's departure from men or from surrounding objects, we may emphasize merely the fact of removal, in which case ἀπέρχομαι, to go away, would be appropriate; or we may emphasize the removal as affecting some relation of the person to that from which he removes, as in John 6:67, where Jesus says to the disciples, "will ye also go away, or withdraw from me," in which case ὑπάγω is the proper word.

In your sin (ἐν τῇ ἁμαρτίᾳ ὑμῶν)

See on Matthew 1:21. Note the singular, sin, not sins. It is used collectively to express the whole condition of estrangement from God.

{8} Then said Jesus again unto them, I go my way, and ye shall seek me, and shall die in your sins: whither I go, ye cannot come.

(8) Because men naturally abhor heavenly things, no man can be a fit disciple of Christ unless the Spirit of God makes him so: in the meantime nonetheless, the world must necessarily perish, because it refuses the life that is offered unto it.

8:21 Whither I go, ye cannot come. Because they shall die in their sins, and he will return to heaven, where the sinner cannot enter.

Margin sins

See Scofield Note: "Rom 3:23".

21-25. Then said Jesus again unto them, I go my way, &c.-(See on [1808]Joh 7:33).

8:21-29 Those that live in unbelief, are for ever undone, if they die in unbelief. The Jews belonged to this present evil world, but Jesus was of a heavenly and Divine nature, so that his doctrine, kingdom, and blessings, would not suit their taste. But the curse of the law is done away to all that submit to the grace of the gospel. Nothing but the doctrine of Christ's grace will be an argument powerful enough, and none but the Spirit of Christ's grace will be an agent powerful enough, to turn us from sin to God; and that Spirit is given, and that doctrine is given, to work upon those only who believe in Christ. Some say, Who is this Jesus? They allow him to have been a Prophet, an excellent Teacher, and even more than a creature; but cannot acknowledge him as over all, God blessed for evermore. Will not this suffice? Jesus here answers the question. Is this to honour him as the Father? Does this admit his being the Light of the world, and the Life of men, one with the Father? All shall know by their conversion, or in their condemnation, that he always spake and did what pleased the Father, even when he claimed the highest honours to himself.